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I have been on Azathioprine for my crohn's disease for over 1 year. I have tried many different medications that were not helping at all. Then after a few alteration of the treatment my doctor suggested moving to Azathioprine rather than other drugs. I started feeling better after just a few days on Azathioprine. At first I noticed minor headache and dizziness but these symptoms son disappeared never to come back again. I am so grateful for Azathioprine!
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If azathioprine is to be discontinued after long term use, it is probably best to taper the dosage rather than discontinue abruptly as a rebound increase immune response can result.

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ASAs work better for ulcerative colitis than for Crohn's disease because ulcerative colitis affects only the lining of the intestines, whereas Crohn's disease affects the deeper layers of the intestines.

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Although CARD15 variants do not predict response to the tumor necrosis factor-alpha monoclonal antibodies, the role of the gene in response to other drugs is not known.

Infusion of rituximab typically causes a 6-month depletion of circulating B cells and therefore may decrease the production of autoantibodies such as ANCAs.

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