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Novel erythropoiesis stimulating protein (NESP), also called darbepoetin alfa (Aranesp), lasts longer in the blood than epoetin alfa and requires fewer injections.

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In contrast, glycosylated biologics and biosimilars, which are considered comparable but distinct from a previously approved product with the same amino acid sequence, receive the root INN of the reference product plus a Greek letter suffix to indicate different glycosylation patterns.

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It should be noted that the terms comparable, similar and highly similar are specific terms used by the EMA and the FDA for the above mentioned purposes (see the FDA website), and so care should be taken in their use; see below.

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