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Few studies have examined the pattern of change over time, so the extent to which people recover function that declines during treatment is not known.
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Novel erythropoiesis stimulating protein (NESP), also called darbepoetin alfa (Aranesp), lasts longer in the blood than epoetin alfa and requires fewer injections.
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In contrast, glycosylated biologics and biosimilars, which are considered comparable but distinct from a previously approved product with the same amino acid sequence, receive the root INN of the reference product plus a Greek letter suffix to indicate different glycosylation patterns.
This group was compared to a control group including 30 patients with hypertensive disease (of the same age and gender) but no history of coronary artery disease or diabetes.
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Humira (adalimumab), PF-06438179, a biosimilar version of Remicade (infliximab), and PF-06439535, a biosimilar version of Genentech's Avastin (bevacizumab).
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It should be noted that the terms comparable, similar and highly similar are specific terms used by the EMA and the FDA for the above mentioned purposes (see the FDA website), and so care should be taken in their use; see below.
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